Through our approach, we are able to advance cannabis science in a way never seen before. Our proprietary genetic database of cannabis plants forms the basis of our API-platform that will enable us, together with our partners, to develop state-of-the-art cannabis-based medicines.
Creating new plant varieties for pharmaceutical production.
Assembling a leading-edge API-platform.
From Proof of Concept to Partnering for Clinical Trials.
The cannabis plant has been cited by world-renowned cannabis researcher Raphael Mechoulam as a “Pharmaceutical Treasure Trove”. This statement comes as no surprise when one looks at the abundance of pharmacological active secondary metabolites and how they interact with our own endocannabinoid system (ECS). The ECS is an endogenous regulatory system that is involved in a large number of physiological processes, such as neurotransmission and the workings of our immune system. It regulates pain, inflammation, immune function, cardiovascular and intestine function, metabolism, memory and motor function. The main function of the ECS is the promotion and regulation of homeostasis on a cellular level. It has a key role in the function of our memory, emotions, addiction, metabolism, pain and neuroprotection. It is rightfully one of our body’s most important regulatory systems.
EndocannabinoidsThe cannabinoids that our body makes.
ReceptorsWhy we react to cannabis and its cannabinoids.
PhytocannabinoidsPlant cannabinoids from Cannabis sativa L.
The cannabis plant (Cannabis sativa L.) is a dioecious, perennial, erect, aromatic herb, with a well-documented use in traditional medicine, all over the world. It is one of the most valuable medicinal plant species in Traditional Chinese and Aryuvedic medicine. The plant is easily recognizable due to the shape of its leaves and aromatic scent. Both of which have become cultural icons nowadays.
The active components of the plant are most abundant on the inflorescences of the female plant. Here, glandular trichomes contain valuable plant oils. These oils contain both the essential oils, comprised of mono- and sesquiterpenes, and a special set of bioactive compounds, called cannabinoids. Both classes of compounds have pharmacological activity on humans. They interact with various bodily systems like the endocannabinoid system, vanilloid system and others.
Terpenes are Generally Recognised As Safe (GRAS), common in nature, and are being used in aromatherapy and as adjuvant in conventional therapies. Examples of cannabis monoterpenes are limonene (also found in citrus fruit), linalool (found in lavender and basil) and myrcene (found in hops and mango fruit). The most predominant sequiterpene in cannabis is beta-caryophyllene (found in pepper). This last one is special because it binds to the CB2-receptor and thus acts as a cannabinoid.
Cannabinoids are a specific set of C-21 molecules, comprised of a terpenoid fraction and a phenol fraction. The cannabinoids are found in the cannabis plant in their acidic form. Decarboxylation (through time and/or heat) will transform them in their neutral (more active) form. The overall effect of cannabis and cannabis extracts on a specific illness or symptom, comes from the terpenoid-cannabinoid synergy. This is known as the cannabis ‘entourage’-effect.
Cannabis as a source for medicine, means a cultivation program that is conducted under fully controlled conditions, in an indoor environment. The botanical raw material needs to be standardized as much as possible in order to extract stable and fully characterizable Active Pharmaceutical Ingredients (API). Pharmaceutical quality control through quality management systems will ensure a transparant production process, according to the current Good Manufacturing Practices (GMP) and ultimately a product of the highest quality, purity, safety and reliability.
Standardization means that in every product from a certain line, the active pharmaceutical ingredients (API) are present in the same concentrations. Optimization means the plant variety from which the botanical raw material is derived, contains a specific and predetermined set of API, to meet the pharmacological need in a certain disease or symptom.
That is why Cannovex goes beyond the highest standards, to ensure that our cannabis genetics meet the rigorous requirements of a pharmaceutical production process.